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Lookup NU author(s): Dr Claire Richardson, Emeritus Professor Paul FlecknellORCiD, Dr Helen Robertson, Professor Alastair BurtORCiD, Professor Derek Manas
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Background. Radiofrequency ablation (RFA) of the liver produces necrosis of the hepatocytes. Histological examination shows a sharp demarcation between ablated and normal liver tissue. This experiment was carried out to study the cellular injury produced by RFA in area surrounding the ablated tissue and effect of reperfusion on this zone. Material and Methods. Five pigs underwent RFA of liver parenchyma. Four pigs were sacrificed 30 min after RFA and one pig was sacrificed 5 days later. Ablated lesions including surrounding liver parenchyma was examined for apoptosis and HSP 70 expression. Results. There was a zone of transition surrounding the necrotic ablated area that showed apoptosis as well as increased HSP 70 expression. This was more prevalent in the pig that was sacrificed 5 days later. Conclusion. RFA produces sub lethal injury in the zone of transition causing apoptosis and increase in HSP 70 expression. Increased HSP expression enhances immunogenicity of these cells that can have therapeutic implications for the treatment of liver. © 2005 Elsevier Inc. All rights reserved.
Author(s): Rai R, Richardson C, Flecknell P, Robertson H, Burt A, Manas DM
Publication type: Article
Publication status: Published
Journal: Journal of Surgical Research
Year: 2005
Volume: 129
Issue: 1
Pages: 147-151
Print publication date: 01/11/2005
ISSN (print): 0022-4804
ISSN (electronic): 1095-8673
Publisher: Academic Press
URL: http://dx.doi.org/10.1016/j.jss.2005.03.020
DOI: 10.1016/j.jss.2005.03.020
PubMed id: 15975593
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