Lookup NU author(s): Dr Hayden Homer,
Dr Mark Levasseur,
Professor Alison Murdoch,
Professor Mary Herbert
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In mitosis, the spindle checkpoint protein Mad2 averts aneuploidy by delaying anaphase onset until chromosomes align. Here we show that depletion of Mad2 in meiosis I mouse oocytes induced an increased incidence of aneuploidy. Proteolysis of cyclin B and securin commenced earlier in Mad2-depleted oocytes, resulting in a shortened duration of meiosis I. Furthermore, overexpression of Mad2 inhibited homolog disjunction. We conclude that Mad2 delays the onset of cyclin B and securin degradation and averts aneuploidy during meiosis I in mammalian oocytes. The data suggest a link between trisomies such as Down syndrome and defective oocyte spindle checkpoint function.
Author(s): Homer HA, McDougall A, Levasseur M, Yallop K, Murdoch AP, Herbert M
Publication type: Article
Publication status: Published
Journal: Genes and Development
ISSN (print): 0890-9369
ISSN (electronic): 1549-5477
Publisher: Cold Spring Harbor Laboratory Press
PubMed id: 15655110
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