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Genetic polymorphism of manganese superoxide dismutase (MnSOD) and breast cancer susceptibility

Lookup NU author(s): Professor Suzanne Cholerton, Professor Ann Daly

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Abstract

Within mitochondria, manganese superoxide dismutase (MnSOD) provides a major defence against oxidative damage by reactive oxygen species (ROS). An alanine-9valine (Ala-9Val) polymorphism in the mitochondrial targeting sequence of MnSOD has been described and has recently been associated with risk of human breast cancer. Our present case-control study was performed to explore the association between MnSOD genetic polymorphism and individual susceptibility to breast cancer. Ala-9Val polymorphism in the signal sequence of the protein for MnSOD was determined using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) assay in a study population. There was no significant difference in risk for breast cancer development between patients positive and negative for the MnSOD Ala allele with adjusted odds ratio (OR): 0.86 (95% confidence interval (CI) 0.43 to 1.72). When MnSOD Ala was combined with either cytochrome P450 1B1 CYP1B1*1 and catechol O-methyltransferase COMT-L (V158M) genotypes, the risk for developing breast cancer was significantly increased in patients with a body mass index (BMI) greater than 24 kg m-2 (OR: 1.42 (95%CI = 1.04-1.93)). Copyright © 2004 John Wiley & Sons, Ltd.


Publication metadata

Author(s): Kocabas NA, Sardas S, Cholerton S, Daly AK, Elhan AH, Karakaya AE

Publication type: Article

Publication status: Published

Journal: Cell Biochemistry and Function

Year: 2005

Volume: 23

Issue: 1

Pages: 73-76

ISSN (print): 0263-6484

ISSN (electronic): 1099-0844

Publisher: John Wiley & Sons Ltd.

URL: http://dx.doi.org/10.1002/cbf.1128

DOI: 10.1002/cbf.1128

PubMed id: 15386537


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