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Lookup NU author(s): Dawn Eddy
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In type 2 diabetes, the onset and progression of complications is significantly delayed by improving glycaemic control. However, the proportion of patients reaching and sustaining guideline recommendations for glycaemic targets remains unacceptably low. Recent clinical trials and predictive physiologically based mathematical simulations (Archimedes model) indicate that benefits can be enhanced with earlier intervention and timely achievement of glycaemic targets. This article reviews the evidence for early intervention, showing that intensive approaches, including earlier introduction of combination therapy, allow more patients to achieve glycaemic targets and hence reduce complications and delay disease progression. © Blackwell Publishing Ltd, 2005.
Author(s): Bailey CJ, Del Prato S, Eddy D, Zinman B, Albetti G, Aschner PP, Blonde L, Felton A-M, Goldstein B, Gomis R, Horton E, LaSalle JJ, Lee H-K, Leiter L, Matthaei S, McGill M, Munro N, Nesto R, Zimmet P
Publication type: Review
Publication status: Published
Journal: International Journal of Clinical Practice
Year: 2005
Volume: 59
Issue: 11
Pages: 1309-1316
ISSN (print): 1368-5031
ISSN (electronic): 1742-1241
URL: http://dx.doi.org/10.1111/j.1742-1241.2005.00675.x
DOI: 10.1111/j.1742-1241.2005.00675.x
PubMed id: 16236086