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Earlier intervention in type 2 diabetes: The case for achieving early and sustained glycaemic control

Lookup NU author(s): Dawn Eddy

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Abstract

In type 2 diabetes, the onset and progression of complications is significantly delayed by improving glycaemic control. However, the proportion of patients reaching and sustaining guideline recommendations for glycaemic targets remains unacceptably low. Recent clinical trials and predictive physiologically based mathematical simulations (Archimedes model) indicate that benefits can be enhanced with earlier intervention and timely achievement of glycaemic targets. This article reviews the evidence for early intervention, showing that intensive approaches, including earlier introduction of combination therapy, allow more patients to achieve glycaemic targets and hence reduce complications and delay disease progression. © Blackwell Publishing Ltd, 2005.


Publication metadata

Author(s): Bailey CJ, Del Prato S, Eddy D, Zinman B, Albetti G, Aschner PP, Blonde L, Felton A-M, Goldstein B, Gomis R, Horton E, LaSalle JJ, Lee H-K, Leiter L, Matthaei S, McGill M, Munro N, Nesto R, Zimmet P

Publication type: Review

Publication status: Published

Journal: International Journal of Clinical Practice

Year: 2005

Volume: 59

Issue: 11

Pages: 1309-1316

ISSN (print): 1368-5031

ISSN (electronic): 1742-1241

URL: http://dx.doi.org/10.1111/j.1742-1241.2005.00675.x

DOI: 10.1111/j.1742-1241.2005.00675.x

PubMed id: 16236086


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