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Mucin gene expression in nasal polyps

Lookup NU author(s): MD Shamsher Ali, Professor Janet Wilson, Dr Mark Bennett, Professor Jeffrey Pearson

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Abstract

Conclusions. A large set of mucin genes is expressed in nasal polyps. The expression pattern is complex and may reflect the wide spectrum of variables involved in polyp formation and progression. Prospective studies including subgroups of nasal polyps and involving substantial numbers of cases in each subgroup will be required to elucidate these variables and to understand how they affect mucus secretion. Objective. At present, 15 of the 19 known mucin genes are expressed in the human airways. Nasal polyps might be expected to have a mucin expression pattern comparable to that of the airways. The aim of this study was to investigate mucin expression in nasal polyps. Material and methods. Nasal polyp samples were obtained from 20 patients during functional endoscopic sinus surgery. Normal (control) sphenoid sinus mucosa was obtained from patients undergoing trans-sphenoid hypophysectomy. The expression of eight mucin genes (MUC1-4, -5AC, -5B, -6 and -7) was studied by in situ hybridization utilizing digoxigenin-labelled oligonucleotide probes. Results. MUC6 and -7 were not expressed in sphenoid sinus mucosa, while all the studied mucin genes were expressed in nasal polyps. Expression patterns varied widely between individual polyps. The predominant epithelial mucin genes were MUC4, -5AC and -3, while MUC5B and -7 were mainly of glandular origin. MUC1, -2 and -6 were weakly expressed. The major alteration in gene expression in nasal polyps was found in the submucosal glands. MUC4 and -5AC represent a major component of both submucosal glands and epithelial cells in nasal polyps. © 2005 Taylor & Francis.


Publication metadata

Author(s): Ali MS, Wilson JA, Bennett M, Pearson JP

Publication type: Article

Publication status: Published

Journal: Acta Oto-Laryngologica

Year: 2005

Volume: 125

Issue: 6

Pages: 618-624

Print publication date: 01/06/2005

ISSN (print): 0001-6489

ISSN (electronic): 1651-2553

Publisher: Informa Healthcare

URL: http://dx.doi.org/10.1080/00016480510027538

DOI: 10.1080/00016480510027538

PubMed id: 16076710


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