Lookup NU author(s): Professor James Shaw,
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Aims. To determine the prevalence of diabetes and its glycemic control in the renal transplant population of northeast England (Newcastle, Sunderland, Middlesborough, and Carlisle). Methods. All renal transplant notes in northeast England were reviewed. Data on patient details, type of diabetes, time of onset of diabetes, diabetes medications, time of insulin commencement, date of renal transplant, immunosuppressive medications, and HbA1C were recorded. Results. Living renal transplant patients (n = 1073) transplanted between March 1982 and November 5, 2003 were identified. One hundred and nine (10.2%) patients had diabetes, of whom 39 were type 1 and 70 were type 2. Median HBA 1C in patients with type 1 diabetes on tacrolimus was 10.1% ± 1.94% (SD) versus 7.8% ± 1.98% (SD) for patients not on tacrolimus. Among patients with type 2 diabetes, 25 had diabetes prior to transplant and 45 (4.5%) developed posttransplant diabetes (PTDM). Those who developed PTDM and were taking tacrolimus were more likely to require insulin for blood glucose control (0.39 U/kg/24 hours vs 0 U/kg/24 hours; P = .05) compared to those not on tacrolimus. Both type 1 and type 2 diabetics on tacrolimus showed better preservation of renal function as measured by mean serum creatinine (type 1: 145 ± 53 vs 196 ± 74, P = .02; type 2 pretransplant: 159 ± 73 vs 172 ± 59, P = .35; type 2 posttransplant: 123 ± 35 vs 167 ± 63, P = .01). Conclusions. Tacrolimus use in renal transplant patients with diabetes appeared to be associated with more problematic blood glucose control; however, it seemed to be better at preserving renal function. Intensive blood glucose monitoring is recommended for this group. © 2005 by Elsevier Inc. All rights reserved.
Author(s): Wong YT, Del-Rio-Martin J, Jaques B, Shaw JAM, Talbot D
Publication type: Conference Proceedings (inc. Abstract)
Publication status: Published
Conference Name: Transplantation Proceedings
Year of Conference: 2005
PubMed id: 16298573
Notes: Issue 8
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