Hypothesis: Epithelial-to-mesenchymal transition is a common cause of chronic allograft failure

Ward, C; Robertson, H; Forrest, IA; Lordan, J; Murphy, D; Dark, JH; Corris, PA; Jones, DEJ; Kirby, JA

doi:10.1016/j.transproceed.2004.12.203

Hypothesis: Epithelial-to-mesenchymal transition is a common cause of chronic allograft failure

Lookup NU author(s): Professor Christopher Ward ORCiD, Dr Helen Robertson, Dr Ian Forrest, Dr James Lordan, Denis Murphy, Professor John Dark, Emeritus Professor Nick Europe-Finner, Professor David Jones, Emeritus Professor John Kirby

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Abstract

Renal, hepatic, and lung allografts are compromised by aggressively deteriorating function. This chronic process is produced by an overall burden of organ damage, but the pathophysiology remains poorly understood. Rates of chronic rejection in the lung, for example, have not substantially improved over the last decade, despite new immunosuppressive drugs and improvements in surgical procedure. We present a hypothesis that epithelial-to-mesenchymal transition is a common cause of chronic allograft failure. Research in this area may provide insights into chronic rejection of kidney, liver, and lung allografts that impact on future therapeutic strategies. © 2005 by Elsevier Inc. All rights reserved.