Lookup NU author(s): Dr Neil Foster,
Dr John Taylor,
Professor Philip Preshaw
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Lipopolysaccharide (LPS) from the Gram-negative pathogen Porphyromonas gingivalis (Pg) stimulates cytokine secretion in immune cells, and thereby initiates the inflammation associated with periodontitis. Modulation of pro-inflammatory cytokine activity is a plausible therapeutic target in periodontal disease. Vasoactive intestinal peptide (VIP) has a role in immunoregulation, and has been identified as a molecule with therapeutically beneficial immunosuppressive effects in inflammatory and autoimmune conditions. We aimed to investigate the effect of VIP on immune responses induced by Pg LPS in vitro. VIP (10-8 M) significantly (P < 0.05) inhibits TNF-α production by human monocytic THP1 cells stimulated with Pg LPS. In parallel, we showed that VIP inhibits nuclear translocation of NFκB and c-Jun in a time-dependent manner, but does not decrease the expression of CD14 receptors. This is the first report to show the potential of VIP as an immunomodulator of Pg-stimulated inflammatory pathways in human monocytes.
Author(s): Foster N, Cheetham J, Taylor JJ, Preshaw PM
Publication type: Article
Publication status: Published
Journal: Journal of Dental Research
Print publication date: 01/11/2005
ISSN (print): 0022-0345
ISSN (electronic): 1544-0591
Publisher: Sage Publications, Inc.
PubMed id: 16246930
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