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VIP inhibits Porphyromonas gingivalis LPS-induced immune responses in human monocytes

Lookup NU author(s): Dr Neil Foster, Jill Cheetham, Dr John TaylorORCiD, Professor Philip Preshaw

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Abstract

Lipopolysaccharide (LPS) from the Gram-negative pathogen Porphyromonas gingivalis (Pg) stimulates cytokine secretion in immune cells, and thereby initiates the inflammation associated with periodontitis. Modulation of pro-inflammatory cytokine activity is a plausible therapeutic target in periodontal disease. Vasoactive intestinal peptide (VIP) has a role in immunoregulation, and has been identified as a molecule with therapeutically beneficial immunosuppressive effects in inflammatory and autoimmune conditions. We aimed to investigate the effect of VIP on immune responses induced by Pg LPS in vitro. VIP (10-8 M) significantly (P < 0.05) inhibits TNF-α production by human monocytic THP1 cells stimulated with Pg LPS. In parallel, we showed that VIP inhibits nuclear translocation of NFκB and c-Jun in a time-dependent manner, but does not decrease the expression of CD14 receptors. This is the first report to show the potential of VIP as an immunomodulator of Pg-stimulated inflammatory pathways in human monocytes.

Publication metadata

Author(s): Foster N, Cheetham J, Taylor JJ, Preshaw PM

Publication type: Article

Publication status: Published

Journal: Journal of Dental Research

Year: 2005

Volume: 84

Issue: 11

Pages: 999-1004

Print publication date: 01/11/2005

ISSN (print): 0022-0345

ISSN (electronic): 1544-0591

Publisher: Sage Publications, Inc.

URL: http://dx.doi.org/10.1177/154405910508401106

DOI: 10.1177/154405910508401106

PubMed id: 16246930

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