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Analysis of peripheral blood T-cell subsets in active thyroid-associated ophthalmopathy: Absence of effect of octreotide-LAR on T-cell subsets in patients with thyroid-associated ophthalmopathy

Lookup NU author(s): Dr Bijayeswar Vaidya, Dr Brian Shenton, Susan Stamp, Dr Alison Dickinson, Dr Petros Perros, Professor Pat Kendall-Taylor

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Abstract

Thyroid-associated Ophthalmopathy (TAO) is thought to be a T-cell-mediated autoimmune disorder. We sought to characterize abnormalities in the peripheral blood T-cell subsets in patients with TAO, and examine whether the long-acting somatostatin analogue, octreotide-LAR, treatment affects these cells. We analyzed peripheral blood T-cell subsets by flow cytometry in 26 euthyroid patients with moderately severe active TAO and 24 controls. Twenty-five of the patients with TAO were enrolled in a randomized trial to receive either 30 mg of octreotide-LAR (n = 11) or placebo (n = 14) every 4 weeks for 16 weeks; all 25 patients subsequently received octreotide-LAR 30 mg every 4 weeks from week 16 to 32. T-cell subsets were analysed at baseline, week 16, and week 32. At baseline, the relative percentage of CD4+ helper T-cells (p = 0.0003) and the CD4+/CD8+ ratio (p = 0.008) were significantly higher in patients with TAO compared to controls. Patients with TAO had higher naïve active T cells (CD45RA+, CD45RA+CD4 +) and lower memory T cells (CD45RO+, CD45RO +CD4+) than controls. At weeks 16 and 32, there were no significant differences in any T-cell subsets between the octreotide-LAR-treated and placebo groups. These results support a role of T cell in the pathogenesis of TAO, and show that octreotide-LAR has no effect on T-cell subsets during 32-weeks of treatment. © Mary Ann Liebert, Inc.


Publication metadata

Author(s): Vaidya B, Shenton BK, Stamp S, Miller M, Baister E, Andrews CD, Dickinson AJ, Perros P, Kendall-Taylor P

Publication type: Article

Publication status: Published

Journal: Thyroid

Year: 2005

Volume: 15

Issue: 9

Pages: 1073-1078

Print publication date: 01/09/2005

ISSN (print): 1050-7256

ISSN (electronic): 1557-9077

Publisher: Mary Ann Liebert, Inc.

URL: http://dx.doi.org/10.1089/thy.2005.15.1073

DOI: 10.1089/thy.2005.15.1073

PubMed id: 16187917


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