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Impact of physical activity on intestinal cancer development in mice

Lookup NU author(s): Dr Laura Basterfield, Professor John Mathers

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Abstract

Observational epidemiology supports the hypothesis that variation in diet and other lifestyle exposures accounts for a large part of the variation in incidence of colorectal cancer (CRC). Physical inactivity is associated strongly with enhanced CRC risk, but no human intervention studies have shown causality. This paper reviews data from all available studies of the effects of exercise interventions on intestinal neoplasia using rat and mouse models. All 5 published studies of effects of increased physical activity (both forced and voluntary) using carcinogen-treated rat models show strong protection against CRC by greater physical activity. In contrast, there is little convincing evidence of reduced intestinal neoplasia after increased physical activity in the 3 published studies using ApcMin mice (which develop multiple intestinal polyps spontaneously) although the nature and amounts of physical activity imposed in rats and mice were similar. Major differences in protocol between the 2 groups of studies are that the rat studies were much longer (at least 20 wk and in most cases 38 wk compared with ≤9 wk for the mouse studies) and the primary endpoint was colorectal carcinoma (rats) rather than small bowel adenomas (mice). The epidemiological evidence for protection against adenoma formation by increased physical activity is weaker than that for carcinoma. The limited evidence available suggests that, compared with rats, mice may show a greater compensation for energy expenditure in exercise through reduction in nonexercise physical activity, thus ameliorating effects. The resulting smaller effects on body weight and body fatness may limit changes in intestinal neoplasia in ApcMin mice. © 2005 American Society for Nutrition.


Publication metadata

Author(s): Basterfield L, Reul JMHM, Mathers JC

Publication type: Conference Proceedings (inc. Abstract)

Publication status: Published

Conference Name: International Research Conference on Diet, Nutrition and Cancer

Year of Conference: 2005

Pages: -

ISSN: 0022-3166

Publisher: Journal of Nutrition, American Society for Nutrition

PubMed id: 16317161

Library holdings: Search Newcastle University Library for this item

ISBN: 15416100


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