Lookup NU author(s): Professor Jeff Errington
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Systematic inactivation of Bacillus subtilis genes has previously revealed that 271 are indispensable for growth. In the present study, 11 of these (YacA, ydiB, ydiC, ykqC, ylaN, yloQ, ymdA, yneS, yqel, yqjK and ywlC) were identified as genes encoding proteins of unknown function. By analysing the effects of protein depletion, and examining the subcellular localization of these proteins, a start has been made in elucidating their functions. It was found that four of these genes (ydiB, yloQ, yqel and ywlC) were not required for B. subtilis viability. Analysis of the localization of YkqC suggests that it co-localizes with ribosomes, and it is proposed that it is involved in processing either rRNA or specific mRNAs when they are associated with the ribosome. The results suggest that other novel essential proteins may be involved in lipid synthesis and control of cell wall synthesis. © 2006 SGM.
Author(s): Hunt A, Rawlins JP, Thomaides HB, Errington J
Publication type: Article
Publication status: Published
Print publication date: 01/10/2006
ISSN (print): 1350-0872
ISSN (electronic): 1465-2080
Publisher: Society for General Microbiology
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