Browse by author
Lookup NU author(s): Professor Mark Cunningham, Dr Claudia RaccaORCiD, Professor Miles Whittington
Full text for this publication is not currently held within this repository. Alternative links are provided below where available.
The level of arousal in mammals is correlated with metabolic state and specific patterns of cortical neuronal responsivity. In particular, rhythmic transitions between periods of high activity (up phases) and low activity (down phases) vary between wakefulness and deep sleep/anesthesia. Current opinion about changes in cortical response state between sleep and wakefulness is split between neuronal network-mediated mechanisms and neuronal metabolism-related mechanisms. Here, we demonstrate that slow oscillations in network state are a consequence of interactions between both mechanisms. Specifically, recurrent networks of excitatory neurons, whose membrane potential is partly governed by ATP-modulated potassium (KATP) channels, mediate response-state oscillations via the interaction between excitatory network activity involving slow, kainate receptor-mediated events and the resulting activation of ATP-dependent homeostatic mechanisms. These findings suggest that KATP channels function as an interface between neuronal metabolic state and network responsivity in mammalian cortex. © 2006 by The National Academy of Sciences of the USA.
Author(s): Cunningham MO, Pervouchine DD, Racca C, Kopell NJ, Davies CH, Jones RSG, Traub RD, Whittington MA
Publication type: Article
Publication status: Published
Journal: Proceedings of the National Academy of Sciences of the United States of America
Year: 2006
Volume: 103
Issue: 14
Pages: 5597-5601
ISSN (print): 0027-8424
ISSN (electronic): 1091-6490
Publisher: National Academy of Sciences
URL: http://dx.doi.org/10.1073/pnas.0600604103
DOI: 10.1073/pnas.0600604103
PubMed id: 16565217
Altmetrics provided by Altmetric
