Lookup NU author(s): Professor Robin Henderson
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A complication of long-term anticoagulation is that the optimal dose level varies not only between patients but over time within patients, in response to short-term changes in lifestyle. Consequently, doseage needs to be adaptive but there are as yet no accepted decision rules. Since anticoagulant use is increasing worldwide there is a need for more objective and routine procedures. In this paper, we describe an analysis of observational longitudinal anticoagulant data, aimed at determining an optimal reactive dose-changing strategy. We use the regret parameterization approach advocated by Murphy (J. R. Stat. Soc. Ser. B 2003; 65:331-366). Practical problems encountered in the implementation of the approach are discussed and illustrated. Copyright © 2006 John Wiley & Sons, Ltd.
Author(s): Rosthoj S, Fullwood C, Henderson R, Stewart S
Publication type: Article
Publication status: Published
Journal: Statistics in Medicine
ISSN (print): 0277-6715
ISSN (electronic): 1097-0258
Publisher: John Wiley & Sons Ltd.
PubMed id: 16981226
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