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A beta2-frequency (20-30 Hz) oscillation in nonsynaptic networks of somatosensory cortex

Lookup NU author(s): Dr Anita Roopun, Dr Steven Middleton, Professor Mark Cunningham, Dr Fiona LeBeau, Professor Miles Whittington

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Abstract

Beta2 frequency (20-30 Hz) oscillations appear over somatosensory and motor cortices in vivo during motor preparation and can be coherent with muscle electrical activity. We describe a beta2 frequency oscillation occurring in vitro in networks of layer V pyramidal cells, the cells of origin of the corticospinal tract. This beta2 oscillation depends on gap junctional coupling, but it survives a cut through layer 4 and, hence, does not depend on apical dendritic electrogenesis. It also survives a blockade of α-amino-3- hydroxy-5-methyl-4-isoxazolepropionic acid receptors or a blockade of GABA A receptors that is sufficient to suppress gamma (30-70 Hz) oscillations in superficial cortical layers. The oscillation period is determined by the M type of K+ current. © 2006 by The National Academy of Sciences of the USA.

Publication metadata

Author(s): Roopun AK, Middleton SJ, Cunningham MO, Le Beau FEN, Bibbig A, Whittington MA, Traub RD

Publication type: Article

Publication status: Published

Journal: Proceedings of the National Academy of Sciences of the United States of America

Year: 2006

Volume: 103

Issue: 42

Pages: 15646-15650

Date deposited: 27/05/2008

ISSN (print): 0027-8424

ISSN (electronic): 1091-6490

Publisher: National Academy of Sciences

URL: http://dx.doi.org/10.1073/pnas.0607443103

DOI: 10.1073/pnas.0607443103

PubMed id: 17030821

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