ePrints

Pathophysiology of synuclein aggregation in Lewy body disease

Lookup NU author(s): Dr Elizabeta Mukaetova-Ladinska, Professor Ian McKeith

Downloads

Full text for this publication is not currently held within this repository. Alternative links are provided below where available.

Abstract

We provide an overview of synaptic pathology in dementia with Lewy bodies (DLB) and related neurodegenerative disorders that are characterised by intraneuronal accumulation of α-synuclein aggregates. The review addresses the clinico-neuropathological correlates of synaptic pathology in Lewy body disease, and concentrates on: altered α-synuclein metabolism, mechanisms leading to α-synuclein fibril formation (self-polymerisation, α-synuclein mutations and post-translational modifications) and how these influence the axonal transport and synaptic network in ageing and disease process. Understanding the mechanisms leading to intraneuronal α-synuclein accumulation are crucial for the development of novel therapies for treatment of Lewy body disease. © 2005 Elsevier Ireland Ltd. All rights reserved.

Publication metadata

Author(s): Mukaetova-Ladinska EB, McKeith IG

Publication type: Article

Publication status: Published

Journal: Mechanisms of Ageing and Development

Year: 2006

Volume: 127

Issue: 2

Pages: 188-202

ISSN (print): 0047-6374

ISSN (electronic): 1872-6216

Publisher: Elsevier Ireland Ltd

URL: http://dx.doi.org/10.1016/j.mad.2005.09.014

DOI: 10.1016/j.mad.2005.09.014

PubMed id: 16297436

Altmetrics

Funding

Share