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Biliary excretion of etoposide in children with cancer

Lookup NU author(s): Professor Gareth Veal, Julie Errington, Huw ThomasORCiD, Professor Alan Boddy

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Abstract

Purpose: Two children with soft tissue sarcomas receiving etoposide as part of their standard clinical treatment had external biliary drainage due to obstruction of the bile duct. These unusual cases provided an opportunity to investigate the biliary clearance of etoposide by determining etoposide concentrations in bile and plasma samples obtained during chemotherapy. Patients and methods: Etoposide was administered to patient 1 at a dose of 150 mg/m 2, as a 4 h infusion, on each of three days of treatment. Patient 2 received a daily etoposide dose of 800 mg/m2 as a 24 h continuous infusion, also over a 3-day treatment period. Bile and plasma samples were obtained at regular intervals from both patients and etoposide levels quantified by LC/MS analysis. Results and discussion: Biliary etoposide clearance was approximately equal to the flow of bile, with an average clearance of 0.32 ml/min determined in patient 1. Less than 2% of the etoposide dose administered was excreted in the bile in either patient studied, indicating that biliary clearance of etoposide is relatively minor. These results suggest that etoposide dose adjustment is unnecessary in patients with biliary obstruction. © Springer-Verlag 2006.

Publication metadata

Author(s): Veal GJ, Errington J, Thomas HD, Boddy AV, Lowis S

Publication type: Article

Publication status: Published

Journal: Cancer Chemotherapy and Pharmacology

Year: 2006

Volume: 58

Issue: 3

Pages: 415-417

Print publication date: 01/09/2006

ISSN (print): 0344-5704

ISSN (electronic): 1432-0843

URL: http://dx.doi.org/10.1007/s00280-005-0180-7

DOI: 10.1007/s00280-005-0180-7

PubMed id: 16418874

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