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Catalytic, asymmetric Strecker reactions catalysed by titanium^IV and vanadium^V(salen) complexes

Lookup NU author(s): Lisa Clutterbuck, Dr Christophe Grosjean, Professor Michael North

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Abstract

VanadiumV(salen) complex 3 has been found to be an effective catalyst for the asymmetric addition of hydrogen cyanide (generated in situ from trimethylsilyl cyanide) to imines. The best results (up to 81% enantiomeric excess) were obtained for aromatic imines in which the nitrogen atom is protected with a benzyl group and in which the imine bond is not sterically encumbered. © 2006 Elsevier Ltd. All rights reserved.

Publication metadata

Author(s): Blacker J, Clutterbuck LA, Crampton MR, Grosjean C, North M

Publication type: Article

Publication status: Published

Journal: Tetrahedron: Asymmetry

Year: 2006

Volume: 17

Issue: 9

Pages: 1449-1456

ISSN (print): 0957-4166

ISSN (electronic): 1362-511X

Publisher: Pergamon

URL: http://dx.doi.org/10.1016/j.tetasy.2006.05.015

DOI: 10.1016/j.tetasy.2006.05.015

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