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Telomere length predicts poststroke mortality, dementia, and cognitive decline

Lookup NU author(s): Dr Carmen Martin-Ruiz, Dr Heather Dickinson, Barbara Keys, Dr Elise Rowan, Professor Rose Anne Kenny, Professor Thomas von Zglinicki

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Abstract

Objective: Long-term cognitive development is variable among stroke survivors, with a high proportion developing dementia. Early identification of those at risk is highly desirable to target interventions for secondary prevention. Telomere length in peripheral blood mononuclear cells was tested as prognostic risk marker. Methods: A cohort of 195 nondemented stroke survivors was followed prospectively from 3 months after stroke for 2 years for cognitive assessment and diagnosis of dementia and for 5 years for survival. Telomere lengths in peripheral blood mononuclear cells were measured at 3 months after stroke by in-gel hybridization. Hazard ratios for survival in relation to telomere length and odds ratios for dementia were estimated using multivariate techniques, and changes in Mini-Mental State Examination scores between baseline and 2 years were related to telomere length using multivariate linear regression. Results: Longer telomeres at baseline were associated with reduced risk for death (hazard ratio for linear trend per 1,000bp = 0.52; 95% confidence interval, 0.28-0.98; p = 0.04, adjusted for age) and dementia (odds ratio for linear trend per 1,000bp = 0.19; 95% confidence interval, 0.07-0.54; p = 0.002) and less reduction in Mini-Mental State Examination score (p = 0.04, adjusted for baseline score). Interpretation: Telomere length is a prognostic marker for poststroke cognitive decline, dementia, and death. © 2006 American Neurological Association.


Publication metadata

Author(s): Martin-Ruiz C, Dickinson HO, Keys B, Rowan E, Kenny RA, von Zglinicki T

Publication type: Article

Publication status: Published

Journal: Annals of Neurology

Year: 2006

Volume: 60

Issue: 2

Pages: 174-180

ISSN (print): 0364-5134

ISSN (electronic): 1531-8249

Publisher: John Wiley & Sons, Inc.

URL: http://dx.doi.org/10.1002/ana.20869

DOI: 10.1002/ana.20869

PubMed id: 16685698


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