Lookup NU author(s): Elizabeth Sconce,
Professor Ann Daly,
Dr Tayyaba Khan,
Dr Hilary Wynne,
Professor Farhad Kamali
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Alterations in vitamin K availability can significantly influence anticoagulation response to warfarin. Apolipoprotein E (APOE) plays a part in the hepatic uptake of lipid-soluble vitamin K. This study aimed to determine the influence of common polymorphisms in the APOE gene on warfarin dose requirements. patients with stable anticoagulation control and with a target International Normalized Ratio (INR) 2.0-3.0 were genotyped for the APOE ε2, ε3 and ε4 variants. Mean±SD daily warfarin doses were significantly lower in patients carrying at least one ε4 allele compared to the ε3ε3 reference genotype (3.3±1.9 versus 4.0±1.8; P=0.03; 95% CI: 0.1-1.2). Multivariate regression analysis showed that patient age, height and CYP2C9, VKORC1 and APOE genotypes significantly contributed to warfarin dose requirement (R=57%). only the ε4 allele of APOE was found to make a significant (P=0.002) but small contribution to warfarin dose requirement. There was no significant difference in fasted plasma vitamin K concentration between patients with the different APOE genotypes. This study suggests that APOE genotype is unlikely to have a clinically significant effect on warfarin dose requirements. © 2006 Lippincott Williams & Wilkins.
Author(s): Sconce EA, Daly AK, Khan TI, Wynne HA, Kamali F
Publication type: Article
Publication status: Published
Journal: Pharmacogenetics and Genomics
ISSN (print): 1744-6872
ISSN (electronic): 1744-6880
Publisher: Lippincott Williams & Wilkins
PubMed id: 16847429
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