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Sprouty and cancer: The first terms report

Lookup NU author(s): Dr Arthur Mckie, Professor Hing Leung

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Abstract

The Ras/Erk signaling pathway has a central role in development of multi-cellular organisms as well as in signal transmission in the mature individual. Recently, a family of genes, designated Sprouty, induced by the Ras/Erk pathway was found to specify proteins that inhibited the upstream pathway. Being in a position that is likely to control well-characterized oncogene products suggested that the expression levels of the Sprouty genes may be relevant in human carcinogenesis. Early data on the deregulation of Sprouty expression in breast, prostate and liver cancers is discussed along with the notion that some of them might have potential as tumour markers or that the derived proteins may act as tumour suppressors. © 2006 Elsevier Ireland Ltd. All rights reserved.

Publication metadata

Author(s): Lo TL, Fong CW, Yusoff P, Mckie AB, Chua MS, Leung HY, Guy GR

Publication type: Article

Publication status: Published

Journal: Cancer Letters

Year: 2006

Volume: 242

Issue: 2

Pages: 141-150

Print publication date: 28/10/2006

ISSN (print): 03043835

ISSN (electronic):

URL: http://dx.doi.org/10.1016/j.canlet.2005.12.032

DOI: 10.1016/j.canlet.2005.12.032

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