Lookup NU author(s): Professor Jeff Errington
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The clinically important vancomycin antibiotic inhibits the growth of pathogens such as Staphylococcus aureus by blocking cell wall synthesis through specific recognition of nascent peptidoglycan terminating in D-Ala-D-Ala. Here, we demonstrate the ability of single-molecule atomic force microscopy with antibiotic-modified tips to measure the specific binding forces of vancomycin and to map individual ligands on living bacteria. The single-molecule approach presented here provides new opportunities for understanding the binding mechanisms of antibiotics and for exploring the architecture of bacterial cell walls. © 2007 American Chemical Society.
Author(s): Gilbert Y, Deghorain M, Wang L, Xu B, Pollheimer PD, Gruber HJ, Errington J, Hallet B, Haulot X, Verbelen C, Hols P, Dufrene YF
Publication type: Article
Publication status: Published
Journal: Nano Letters
Print publication date: 01/03/2007
ISSN (print): 1530-6984
ISSN (electronic): 1530-6992
Publisher: American Chemical Society
PubMed id: 17316058
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