Lookup NU author(s): MD Shamsher Ali,
Professor Janet Wilson,
Dr Mark Bennett,
Professor Jeffrey Pearson
Full text for this publication is not currently held within this repository. Alternative links are provided below where available.
Conclusion. Membrane-bound mucin MUC4 represents the predominant mucin expressed in the adenoid epithelium followed by MUC5AC (gel-forming mucin). This may suggest that membrane-bound mucins could be involved in pathogen binding and immunological stimulation. Objectives: The aim of this study was to investigate mucin expression in hypertrophic adenoids. Materials and methods. Adenoidal samples were obtained from 12 children. The expression of eight mucin genes, MUC1-4, MUC5AC, 5B, 6 and 7 was studied by in situ hybridization utilizing digoxigenin-labelled oligonucleotide probes. Results. The dominant mucin genes were MUC4, 3 and 5AC, while MUC1, 2, 5B and 7 were sparsely expressed and MUC6 was not expressed. Expression patterns were very different from those in the upper airways. Most samples expressed two membrane-bound mucins (MUC4 and 3) and one secretory mucin (MUC5AC). © 2007 Taylor & Francis.
Author(s): Ali MS, Wilson JA, Bennett MK, Pearson JP
Publication type: Article
Publication status: Published
Journal: Acta Oto-Laryngologica
ISSN (print): 0001-6489
ISSN (electronic): 1651-2553
Publisher: Informa Healthcare
PubMed id: 17851936
Altmetrics provided by Altmetric