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Mucin gene expression in hypertrophic adenoids

Lookup NU author(s): M Shamsher Ali, Professor Janet Wilson, Dr Mark Bennett, Professor Jeffrey Pearson

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Abstract

Conclusion. Membrane-bound mucin MUC4 represents the predominant mucin expressed in the adenoid epithelium followed by MUC5AC (gel-forming mucin). This may suggest that membrane-bound mucins could be involved in pathogen binding and immunological stimulation. Objectives: The aim of this study was to investigate mucin expression in hypertrophic adenoids. Materials and methods. Adenoidal samples were obtained from 12 children. The expression of eight mucin genes, MUC1-4, MUC5AC, 5B, 6 and 7 was studied by in situ hybridization utilizing digoxigenin-labelled oligonucleotide probes. Results. The dominant mucin genes were MUC4, 3 and 5AC, while MUC1, 2, 5B and 7 were sparsely expressed and MUC6 was not expressed. Expression patterns were very different from those in the upper airways. Most samples expressed two membrane-bound mucins (MUC4 and 3) and one secretory mucin (MUC5AC). © 2007 Taylor & Francis.


Publication metadata

Author(s): Ali MS, Wilson JA, Bennett MK, Pearson JP

Publication type: Article

Publication status: Published

Journal: Acta Oto-Laryngologica

Year: 2007

Volume: 127

Issue: 10

Pages: 1080-1085

ISSN (print): 0001-6489

ISSN (electronic): 1651-2553

Publisher: Informa Healthcare

URL: http://dx.doi.org/10.1080/00016480701200236

DOI: 10.1080/00016480701200236

PubMed id: 17851936


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