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Intracerebroventricular injection of glucagon-like peptide-1 changes lipid metabolism in chicks

Lookup NU author(s): Dr Timothy Boswell

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Abstract

Glucagon-like peptide-1 (GLP-1), derived from proglucagon, is thought to act as a negative regulator of energy homeostasis in mammals, since intracerebroventricular (ICV) injection of GLP-1 inhibits feeding behavior and enhances energy expenditure. The anorexigenic effect of GLP-1 is also observed in chicks, but whether brain GLP-1 enhances energy expenditure has not been investigated. The aim of the present study was to clarify the effect of ICV injection of GLP-1 on energy expenditure as well as metabolic changes in chicks. The injection of GLP-1 did not affect energy expenditure calculated from oxygen consumption and carbon dioxide production. On the other hand, the injection of GLP-1 significantly decreased respiratory quotient, suggesting that brain GLP-1 shifted the use of energy sources from carbohydrates to lipids. In support of this, ICV injection of GLP-1 increased plasma non-esterified fatty acid concentration while plasma glucose concentration was decreased. In conclusion, GLP-1 appears to act in the brain as a metabolic modulator rather than as a regulator of total energy expenditure in chicks. © 2007 Elsevier Inc. All rights reserved.


Publication metadata

Author(s): Tachibana T, Oikawa D, Adachi N, Boswell T, Furuse M

Publication type: Article

Publication status: Published

Journal: Comparative Biochemistry and Physiology - A Molecular and Integrative Physiology

Year: 2007

Volume: 147

Issue: 4

Pages: 1104-1108

Print publication date: 01/08/2007

ISSN (print): 1095-6433

ISSN (electronic): 1531-4332

Publisher: Elsevier

URL: http://dx.doi.org/10.1016/j.cbpa.2007.03.023

DOI: 10.1016/j.cbpa.2007.03.023

PubMed id: 17466552


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