Toggle Main Menu Toggle Search

Open Access padlockePrints

Impairment of hippocampal gamma (γ)-frequency oscillations in vitro in mice overexpressing human amyloid precursor protein (APP)

Lookup NU author(s): Dr Claudia Racca, Professor Mark Cunningham, Professor Miles Whittington, Dr Fiona LeBeau

Downloads

Full text for this publication is not currently held within this repository. Alternative links are provided below where available.


Abstract

Alzheimer's disease is associated with a dramatic decline in cognitive performance including hippocampal-dependent memory. We have investigated one feature of hippocampal activity related to memory, the γ (30-80 Hz)-frequency rhythm. Hippocampal slices from mice overexpressing the human amyloid precursor protein (APP)SWE mutation (TAS10) were compared at 8 and 16 months of age with wild-type littermates. In slices obtained from TAS10 mice aged 8 months the γ-frequency activity evoked with bath application of 200 nm kainate was significantly (P < 0.05; n = 8 slices, five animals) impaired (area power, 5956 ± 2487 μV2) compared to slices from wild-type animals (area power, 18 256 ± 7880 μV2). At 16 months of age there was no longer a significant difference (P > 0.05; n = 11 slices from five animals) between slices from TAS10 and wild-type control mice as the wild-type mice now exhibited a marked age-dependent reduction in γ-frequency activity (TAS10 area power, 5751 ± 1573 μV 2; wild-type area power = 5379 ± 1454 μV2). Although no dense-core plaques were evident at 8 months there was detectable amyloid labelling in the TAS10 mice which might account for the deficits in γ activity observed at this age. Dense plaques were clearly evident in the TAS10, but not wild-type, mice at 16 months of age but no further reductions in γ-frequency activity were seen in the TAS10 mice. These data suggest that deficits in network function in Alzheimer's disease occur early and are not directly correlated to amyloid load. © The Authors (2007).


Publication metadata

Author(s): Driver JE, Racca C, Cunningham MO, Towers SK, Davies CH, Whittington MA, Le Beau FEN

Publication type: Article

Publication status: Published

Journal: European Journal of Neuroscience

Year: 2007

Volume: 26

Issue: 5

Pages: 1280-1288

ISSN (print): 0953-816X

ISSN (electronic): 1460-9568

Publisher: Wiley-Blackwell Publishing Ltd.

URL: http://dx.doi.org/10.1111/j.1460-9568.2007.05705.x

DOI: 10.1111/j.1460-9568.2007.05705.x

PubMed id: 17767505


Altmetrics

Altmetrics provided by Altmetric


Actions

Find at Newcastle University icon    Link to this publication


Share