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Endogenous neurogenesis in the human brain following cerebral infarction

Lookup NU author(s): Emeritus Professor Robert Perry

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Abstract

Increased endogenous neurogenesis has a significant regenerative role in many experimental models of cerebrovascular diseases, but there have been very few studies in humans. We therefore examined whether there was evidence of altered endogenous neurogenesis in an 84-year-old patient who suffered a cerebrovascular accident 1 week prior to death. Using antibodies that specifically label neural stem/neural progenitor cells, we examined the presence of immunopositive cells around and distant from the infarcted area, and compared this with a control, age-matched individual. Interestingly, a large number of neural stem cells, vascular endothelial growth factor-immunopositive cells and new blood vessels were observed only around the region of infarction, and none in the corresponding brain areas of the healthy control. In addition, an increased number of neural stem cells was observed in the neurogenic region of the lateral ventricle wall. Our results suggest increased endogenous neurogenesis associated with neovascularization and migration of newly-formed cells towards a region of cerebrovascular damage in the adult human brain and highlight possible mechanisms underlying this process. © 2007 Future Medicine Ltd.

Publication metadata

Author(s): Minger SL, Ekonomou A, Carta EM, Chinoy A, Perry RH, Ballard CG

Publication type: Article

Publication status: Published

Journal: Regenerative Medicine

Year: 2007

Volume: 2

Issue: 1

Pages: 69-74

ISSN (print): 1746-0751

ISSN (electronic): 1746-076X

Publisher: Future Medicine Ltd.

URL: http://dx.doi.org/10.2217/17460751.2.1.69

DOI: 10.2217/17460751.2.1.69

PubMed id: 17465777

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