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A randomized comparison of selective broadband UVB and narrowband UVB in the treatment of psoriasis

Lookup NU author(s): Dr James Lloyd, Emeritus Professor Brian Diffey, Professor John Matthews, Professor Peter Farr

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Abstract

UVB is widely used to treat psoriasis. Conventional broadband UVB lamps are less effective than narrowband UVB lamps, which have an emission peak at 311 nm. The long-term safety of narrowband UVB phototherapy is uncertain. "Selective" broadband UVB lamps, which have little emission <290 nm, are also available, but have not been adequately compared to narrowband UVB lamps. We performed a randomized comparison of narrowband UVB (TL-01 lamps) and selective broadband UVB (UV6 lamps) in 100 patients with psoriasis. The median number of exposures for clearance was 28.4 for TL-01 and 30.4 for UV6 (ratio of the medians 0.93; 95% confidence interval (CI) 0.80, 1.09; P=0.39). No significant difference was found in the proportion of patients achieving clearance: TL-01 56%, UV6 40% (odds ratio for clearance with TL-01 relative to UV6 was 2.00 (95% CI 0.87, 4.62), P=0.10). Side effects, including the development of erythema during phototherapy, were similar for the two lamp types. Risk estimates based on the human photocarcinogenesis action spectrum predict that narrowband UVB lamps will be 50% more carcinogenic for equal erythemal doses than selective broadband lamps (UV6). As these two lamp types appear to be of similar efficacy, phototherapy using a selective broadband source may be a safer option than use of narrowband UVB. © 2007 The Society for Investigative Dermatology.


Publication metadata

Author(s): Kirke SM, Lowder S, Lloyd JJ, Diffey BL, Matthews JNS, Farr PM

Publication type: Article

Publication status: Published

Journal: Journal of Investigative Dermatology

Year: 2007

Volume: 127

Issue: 7

Pages: 1641-1646

Print publication date: 01/07/2007

ISSN (print): 0022-202X

ISSN (electronic): 1523-1747

Publisher: Nature Publishing Group

URL: http://dx.doi.org/10.1038/sj.jid.5700767

DOI: 10.1038/sj.jid.5700767

PubMed id: 17380117


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