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Trichomonas vaginalis surface proteins: a view from the genome

Lookup NU author(s): Professor Robert Hirt, Dr Christophe Noel

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Abstract

Surface proteins of mucosal microbial pathogens play multiple and essential roles in initiating and sustaining the colonization of the heavily defended mucosa. The protist Trichomonas vaginalis is one of the most common human sexually transmitted pathogens that colonize the urogenital mucosa. However, little is known about its surface proteins. The recently completed draft genome sequence of T. vaginalis provides an invaluable resource to guide molecular and cellular characterization of surface proteins and to investigate their role in pathogenicity. Here, we review the existing data on T. vaginalis surface proteins and summarize some of the main findings from the recent in silico characterization of its candidate surface proteins. © 2007 Elsevier Ltd. All rights reserved.


Publication metadata

Author(s): Hirt RP, Noel CJ, Sicheritz-Ponten T, Tachezy J, Fiori P-L

Publication type: Review

Publication status: Published

Journal: Trends in Parasitology

Year: 2007

Volume: 23

Issue: 11

Pages: 540-547

Print publication date: 01/11/2007

ISSN (print): 1471-4922

ISSN (electronic): 1471-5007

URL: http://dx.doi.org/10.1016/j.pt.2007.08.020

DOI: 10.1016/j.pt.2007.08.020

PubMed id: 17962075


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