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Marine actinobacteria: new opportunities for natural product search and discovery

Lookup NU author(s): Professor Alan Bull, Dr James Stach

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Abstract

It is widely accepted that new drugs, especially antibiotics, are urgently required, and that the most propitious source remains natural products. We argue that in exploring new sources of bioactive natural products the marine environment warrants particular attention, in view of the remarkable diversity of microorganisms and metabolic products. Recent reports of new chemical entities and first-in-class drug candidates, and confirmation of indigenous marine actinobacteria, make exciting discoveries even more likely given the unrivalled capacity of this class of bacteria to produce exploitable natural products. © 2007 Elsevier Ltd. All rights reserved.


Publication metadata

Author(s): Bull AT, Stach JEM

Publication type: Review

Publication status: Published

Journal: Trends in Microbiology

Year: 2007

Volume: 15

Issue: 11

Pages: 491-499

Print publication date: 01/11/2007

ISSN (print): 0966-842X

ISSN (electronic): 1878-4380

URL: http://dx.doi.org/10.1016/j.tim.2007.10.004

DOI: 10.1016/j.tim.2007.10.004

PubMed id: 17997312


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