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The epidemiology of atypical mycobacterial diseases in northern England: A space-time clustering and Generalized Linear Modelling approach

Lookup NU author(s): Professor Stephen Rushton, Emeritus Professor Michael Goodfellow, Professor Anthony O'Donnell, Professor John Magee

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Abstract

The incidence of infection by mycobacteria, other than tubercle bacilli (MOTT) is increasing in the United Kingdom, Europe and the United States. These diseases increase morbidity and are an increasing public health concern. However, the epidemiology of disease due to these species is not well characterized. We used space-time clustering approaches and Generalized Linear Modelling to investigate the potential predictors of disease in cases of infection by organisms of the Mycobacterium avium complex (MAC) and M. malmoense recorded in the north of England during 2000-2005. There was significant spatial and temporal clustering in juvenile cases of infection by MAC but not for cases of infection in adults by either species. There were no significant predictors of infection by M. malmoense or juvenile cases of M. avium. Incidence of disease caused by M. avium in adults was significantly related to health deprivation and weakly related to rainfall. We consider possible reasons for the difference in epidemiology in infection by M. avium in adults and juveniles. © 2006 Cambridge University Press.


Publication metadata

Author(s): Rushton SP, Goodfellow M, O'Donnell AG, Magee JG

Publication type: Article

Publication status: Published

Journal: Epidemiology and Infection

Year: 2007

Volume: 135

Issue: 5

Pages: 765-774

Print publication date: 01/06/2007

ISSN (print): 0950-2688

ISSN (electronic): 1469-4409

Publisher: Cambridge University Press

URL: http://dx.doi.org/10.1017/S0950268806007424

DOI: 10.1017/S0950268806007424

PubMed id: 17083748


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