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Preliminary observation of elevated levels of nanocrystalline iron oxide in the basal ganglia of neuroferritinopathy patients

Lookup NU author(s): Dr Christopher Morris, Andrew Curtis, Professor Sir John Burn

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Abstract

Magnetometry analysis of brain tissue sub-samples from two neuroferritinopathy patients provides a preliminary indication that the amount of magnetic iron compounds associated with this rare disease is significantly larger than in age/sex-matched controls. The primary iron compounds contributing to the remnant magnetization of the tissue above 50 K and at body temperature are both blocked and superparamagnetic (SPM) biogenic magnetite (Fe3O4) and/or maghemite (γ-Fe2O3). The concentration of SPM magnetite is significant and appears to be proportional to the concentration of ferritin, which varies with progression of the disease. The mutated ferritin protein appears to be responsible for the presence of iron oxide nano-particules, which in turn could be responsible for extensive damage in the brain. © 2006 Elsevier B.V. All rights reserved.


Publication metadata

Author(s): Hautot D, Pankhurst QA, Morris CM, Curtis A, Burn J, Dobson J

Publication type: Article

Publication status: Published

Journal: Biochimica et Biophysica Acta - Molecular Basis of Disease

Year: 2007

Volume: 1772

Issue: 1

Pages: 21-25

Print publication date: 01/01/2007

ISSN (print): 0925-4439

Publisher: Elsevier BV

URL: http://dx.doi.org/10.1016/j.bbadis.2006.09.011

DOI: 10.1016/j.bbadis.2006.09.011

PubMed id: 17097860


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