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Diversity and conservation of interactions for binding heme in b-type heme proteins

Lookup NU author(s): Dr Jon Marles-Wright

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Abstract

The heme prosthetic group is vital to many cellular processes and is therefore widespread throughout organisms of different phylogenetic origin. Heme is used in proteins involved in cellular respiration, acts as a chemical mediator in ligand binding and signalling proteins, and is the key co-factor in many enzymes. Strikingly, there are over 20 different folding topologies of b-type heme proteins that are able to incorporate the same, chemically identical heme ligand. Comparisons of structures show that heme-protein interactions are generally diverse, though a degree of conservation exists at contacts with the pyrrole rings, the propionate groups and the proximal ligand. These interaction "hot spots" presumably define major determinants for binding heme and provide guidelines for the future design of novel heme proteins. © The Royal Society of Chemistry.


Publication metadata

Author(s): Schneider S, Marles-Wright J, Sharp KH, Paoli M

Publication type: Review

Publication status: Published

Journal: Natural Product Reports

Year: 2007

Volume: 24

Issue: 3

Pages: 621-630

ISSN (print): 0265-0568

ISSN (electronic): 1460-4752

URL: http://dx.doi.org/10.1039/b604186h

DOI: 10.1039/b604186h

PubMed id: 17534534


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