Lookup NU author(s): Dr Catherine Todhunter,
Dr John Mansfield
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A genome-wide association scan in individuals with Crohn's disease by the Wellcome Trust Case Control Consortium detected strong association at four novel loci. We tested 37 SNPs from these and other loci for association in an independent case-control sample. We obtained replication for the autophagy-inducing IRGM gene on chromosome 5q33.1 (replication P = 6.6 × 10-4, combined P = 2.1 × 10-10) and for nine other loci, including NKX2-3, PTPN2 and gene deserts on chromosomes 1q and 5p13. © 2007 Nature Publishing Group.
Author(s): Parkes M, Barrett JC, Prescott NJ, Tremelling M, Anderson CA, Fisher SA, Roberts RG, Nimmo ER, Cummings FR, Soars D, Drummond H, Lees CW, Khawaja SA, Bagnall R, Burke DA, Todhunter CE, Ahmad T, Onnie CM, McArdle W, Strachan D, Bethel G, Bryan C, Lewis CM, Deloukas P, Forbes A, Sanderson J, Jewell DP, Satsangi J, Mansfield JC, Cardon L, Mathew CG
Publication type: Article
Publication status: Published
Journal: Nature Genetics
Print publication date: 01/07/2007
ISSN (print): 1061-4036
ISSN (electronic): 1546-1718
Publisher: Nature Publishing Group
PubMed id: 17554261
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