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An experimentally induced duplication of retinotopic mapping within the hamster primary visual cortex

Lookup NU author(s): Professor Andrew Trevelyan

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Abstract

Primary cortical areas normally have a single mapping of the receptor array arising from a 'point-to-point' projection from the thalamus. We show that, for the visual cortex, this simple mapping rule breaks down when retinal input to the thalamus is altered. We utilize the monocular enucleation paradigm, which alters subcortical mappings ipsilateral to the remaining eye. We show that this manipulation produces an altered visuotopic map in area 17 with two separated, mirror-imaged representations of the central visual field. Furthermore, thalamic point-to-point connectivity is dramatically changed. There are now two overlapping geniculocortical projections: the predominant projection maps with apparently normal topography, and a second projection maps with the opposite polarity. The plane of symmetry of the duplicated anatomical projection coincides precisely with the functional map reversal and, notably, geniculocortical magnification factors are identical in the two projections. We suggest that the duplicated, abnormal geniculocortical projection is retinotopically matched to the normal projection. We speculate that aberrant geniculocortical terminals are stabilized because they have coherent activity patterns with topographically normal terminals. © The Authors (2007).


Publication metadata

Author(s): Trevelyan AJ, Upton AL, Cordery PM, Thompson ID

Publication type: Article

Publication status: Published

Journal: European Journal of Neuroscience

Year: 2007

Volume: 26

Issue: 11

Pages: 3277-3290

ISSN (print): 0953-816X

ISSN (electronic): 1460-9568

Publisher: Wiley-Blackwell Publishing Ltd.

URL: http://dx.doi.org/10.1111/j.1460-9568.2007.05941.x

DOI: 10.1111/j.1460-9568.2007.05941.x

PubMed id: 18005057


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