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ZAP70 in chronic lymphocytic leukaemia

Lookup NU author(s): Professor Jelena Mann

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Abstract

The protein tyrosine kinase zeta-chain associated protein kinase (ZAP70), normally expressed in T cells and a subset of B cells, is solely expressed in poor prognosis chronic lymphocytic leukaemia and implicated in enhanced B cell receptor signalling. As a result, the expression of this protein provides an ideal prognostic marker for the disease. A previous study has shown differential CpG methylation of a 5′ region of ZAP70 in leukaemic lymphoid cells, although no further epigenetic studies have been reported. Further investigation into the expression of ZAP70 may therefore provide targets for therapies. © 2007 Elsevier Ltd. All rights reserved.

Publication metadata

Author(s): Amin S, Parker A, Mann J

Publication type: Article

Publication status: Published

Journal: International Journal of Biochemistry and Cell Biology

Year: 2008

Volume: 40

Issue: 9

Pages: 1654-1658

ISSN (print): 1357-2725

ISSN (electronic): 1878-5875

Publisher: Pergamon

URL: http://dx.doi.org/10.1016/j.biocel.2007.05.016

DOI: 10.1016/j.biocel.2007.05.016

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