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Advances in Hematopoietic Stem Cell Transplantation for Primary Immunodeficiency

Lookup NU author(s): Professor Andrew GenneryORCiD, Professor Andrew Cant

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Abstract

The molecular bases of most primary immunodeficiencies (PID) have been discovered. Long-term follow-up of patient cohorts treated with antimicrobial prophylaxis has demonstrated good short-term prognosis but with increasing morbidity and mortality over time. The results of hematopoietic stem cell transplantation (HSCT) for PID have improved incrementally over time, with survival and cure of 90% for some defined diseases. This article examines the advances in HSCT for PID and argues that HSCT should be considered earlier for most patients. © 2008 Elsevier Inc. All rights reserved.

Publication metadata

Author(s): Gennery AR, Cant AJ

Publication type: Article

Publication status: Published

Journal: Immunology and Allergy Clinics of North America

Year: 2008

Volume: 28

Issue: 2

Pages: 439-456

ISSN (print): 0889-8561

ISSN (electronic): 1557-8607

Publisher: W.B. Saunders Co.

URL: http://dx.doi.org/10.1016/j.iac.2008.01.006

DOI: 10.1016/j.iac.2008.01.006

PubMed id: 18424341

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