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Increased Platelet-monocyte Aggregation in Male Claudicants with the PlA1/A2 Polymorphism of Gp IIb/IIIa

Lookup NU author(s): Professor Ann Daly, Professor Gerard Stansby

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Abstract

Objectives: To investigate the relationship between the PlA1/A2 polymorphism and platelet activation and aggregation in patients with Peripheral Arterial Disease (PAD). Design: A prospective single-centre cohort study. Methods: 45 patients with PAD on aspirin 75 mg were recruited and phenotyped/genotyped for the Gp IIb/IIIa PlA1/A2 polymorphism. Platelet-Monocyte Aggregation (PMAs) was evaluated using flow-cytometry. Results: The formation of PMAs in the PlA2 group was higher but not statistically significant (p = 0.17). However, when males were analysed separately, the formation of PMAs was significantly higher in the PlA2 group (p = 0.0192). No difference was seen in the females. Conclusions: In this study we show that the PlA1/A2 polymorphism primarily affects the aggregation of platelets to monocytes in males. The effect is not observed in females and understanding the mechanism behind this may help elucidate the way the polymorphism alters platelet function in the presence of aspirin. © 2008 European Society for Vascular Surgery.


Publication metadata

Author(s): McCaslin J, Ashour H, Bhattacharya V, Cleanthis M, Daly A, Stansby G

Publication type: Article

Publication status: Published

Journal: European Journal of Vascular and Endovascular Surgery

Year: 2008

Volume: 36

Issue: 2

Pages: 132-137

ISSN (print): 1078-5884

ISSN (electronic): 1532-2165

Publisher: Elsevier Ltd

URL: http://dx.doi.org/10.1016/j.ejvs.2008.02.016

DOI: 10.1016/j.ejvs.2008.02.016

PubMed id: 18396070


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