Lookup NU author(s): Dr Celine Cano,
Professor Bernard Golding,
Dr Ian Hardcastle,
Professor Nicola Curtin,
Professor Roger Griffin
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The synthesis and biological evaluation of libraries of 8-biarylchromen-4-ones enabled the elucidation of structure-activity relationships for inhibition of the DNA-dependent protein kinase (DNA-PK), with 8-(3-(thiophen-2-yl)phenyl)chromen-4-one and 8-(3-(thiophen-3-yl)phenyl)chromen-4-one being especially potent inhibitors. © 2008 Elsevier Ltd. All rights reserved.
Author(s): Murr M, Cano C, Golding BT, Hardcastle IR, Hummersome M, Frigerio M, Curtin NJ, Menear K, Richardson C, Smith G, Griffin R
Publication type: Article
Publication status: Published
Journal: Bioorganic and Medicinal Chemistry Letters
ISSN (print): 0960-894X
ISSN (electronic): 1464-3405
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