Lookup NU author(s): Professor John O'Brien,
Dr Sean Colloby,
Dr Sanjeet Pakrasi,
Emeritus Professor Elaine Perry,
Professor Ian McKeith,
Professor David Williams
Full text for this publication is not currently held within this repository. Alternative links are provided below where available.
Introduction: To investigate in vivo differences in the distribution of α4β2 subtypes of nAChR using the ligand 123I-5-Iodo-3-[2(S)-2-azetidinylmethoxy] pyridine (5IA-85380) and single photon emission computed tomography (SPECT) in DLB and similarly aged controls. Methods: Thirty-one subjects (15 DLB and 16 controls) underwent 123I-5IA-85380 and perfusion (99mTc-exametazime) SPECT scanning. Patient scans were compared to scans of control subjects on a voxel-by-voxel basis using SPM2. Results: Compared to controls, significant reductions in relative 123I-5IA-85380 uptake were identified in frontal, striatal, temporal and cingulate regions in DLB. Elevation of scaled 123I-5IA-85380 uptake in occipital cortex was observed in DLB relative to controls, as well as being associated with DLB subjects with a recent history of visual hallucinations. Changes in 123I-5IA-85380 SPECT in DLB were different from perfusion. Conclusion: Reductions in normalised 123I-5IA-85380 uptake in DLB were distinct from their perfusion deficits. Significant increase in occipital lobe uptake was present in DLB, a change most pronounced in subjects with a recent history of visual hallucinations. The findings directly link cholinergic changes in occipital lobe to visual hallucinations in DLB. © 2008 Elsevier Inc. All rights reserved.
Author(s): O'Brien JT, Colloby SJ, Pakrasi S, Perry EK, Pimlott SL, Wyper DJ, McKeith IG, Williams ED
Publication type: Article
Publication status: Published
ISSN (print): 1053-8119
ISSN (electronic): 1095-9572
Publisher: Academic Press
PubMed id: 18295510
Altmetrics provided by Altmetric