Lookup NU author(s): Dr Susan Campbell,
Dr Ali Aldibbiat,
Dr Clive Butler,
Professor James Shaw
Full text for this publication is not currently held within this repository. Alternative links are provided below where available.
The present study investigated the role of selenium in the regulation of pancreatic beta-cell function. Utilising the mouse beta-cell line Min6, we have shown that selenium specifically upregulates Ipf1 (insulin promoter factor 1) gene expression, activating the -2715 to -1960 section of the Ipf1 gene promoter. Selenium increased both Ipf1 and insulin mRNA levels in Min6 cells and stimulated increases in insulin content and insulin secretion in isolated primary rat islets of Langerhans. These data are the first to implicate selenium in the regulation of specific beta-cell target genes and suggest that selenium potentially promotes an overall improvement in islet function. © 2008 Federation of European Biochemical Societies.
Author(s): Campbell SC, Aldibbiat A, Marriott CE, Landy C, Ali T, Ferris WF, Butler CS, Shaw JA, Macfarlane WM
Publication type: Article
Publication status: Published
Journal: FEBS Letters
ISSN (print): 0014-5793
ISSN (electronic): 1873-3468
Publisher: Elsevier BV
PubMed id: 18538137
Altmetrics provided by Altmetric