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Selenium stimulates pancreatic beta-cell gene expression and enhances islet function

Lookup NU author(s): Dr Susan Campbell, Dr Ali Aldibbiat, Dr Clive Butler, Professor James Shaw

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Abstract

The present study investigated the role of selenium in the regulation of pancreatic beta-cell function. Utilising the mouse beta-cell line Min6, we have shown that selenium specifically upregulates Ipf1 (insulin promoter factor 1) gene expression, activating the -2715 to -1960 section of the Ipf1 gene promoter. Selenium increased both Ipf1 and insulin mRNA levels in Min6 cells and stimulated increases in insulin content and insulin secretion in isolated primary rat islets of Langerhans. These data are the first to implicate selenium in the regulation of specific beta-cell target genes and suggest that selenium potentially promotes an overall improvement in islet function. © 2008 Federation of European Biochemical Societies.


Publication metadata

Author(s): Campbell SC, Aldibbiat A, Marriott CE, Landy C, Ali T, Ferris WF, Butler CS, Shaw JA, Macfarlane WM

Publication type: Article

Publication status: Published

Journal: FEBS Letters

Year: 2008

Volume: 582

Issue: 15

Pages: 2333-2337

ISSN (print): 0014-5793

ISSN (electronic): 1873-3468

Publisher: Elsevier BV

URL: http://dx.doi.org/10.1016/j.febslet.2008.05.038

DOI: 10.1016/j.febslet.2008.05.038

PubMed id: 18538137


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