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Epigenetic regulation of hepatic stellate cell activation

Lookup NU author(s): Professor Derek Mann, Professor Jelena Mann

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Abstract

Activation of hepatic stellate cells (HSC) to a myofibroblast-like phenotype is the pivotal event in liver fibrosis. In uninjured liver, HSC are quiescent and non-dividing, but upon liver injury these cells undergo a dramatic change in phenotype which generates activated myofibroblast-like HSC. The change in phenotype is underpinned by a global change in gene expression with hundreds of genes being up- or downregulated. Molecular events that orchestrate changes in gene expression take place at the level of chromatin packaging which is altered through three main processes: histone modifications, DNA methylation, and silencing by non-coding RNAs. The present review focuses on the epigenetic regulation of HSC activation. © 2007 The Authors.


Publication metadata

Author(s): Mann DA, Mann J

Publication type: Conference Proceedings (inc. Abstract)

Publication status: Published

Conference Name: Journal of Gastroenterology and Hepatology: 2nd International Symposium on Alcoholic Liver and Pancreatic Diseases and Cirrhosis

Year of Conference: 2008

Pages: S108-S111

ISSN: 0815-9319

Publisher: Wiley-Blackwell Publishing Asia

URL: http://dx.doi.org/10.1111/j.1440-1746.2007.05295.x

DOI: 10.1111/j.1440-1746.2007.05295.x

Library holdings: Search Newcastle University Library for this item

ISBN: 14401746


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