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β-adrenergic receptors are differentially expressed in distinct interneuron subtypes in the rat hippocampus

Lookup NU author(s): Dr David Cox, Dr Claudia Racca, Dr Fiona LeBeau

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Abstract

Noradrenaline (NA) acting via β-adrenergic receptors (βARs) plays an important role in the modulation of memory in the hippocampus. βARs have been shown to be expressed in principal cells, but their distribution across different interneuron classes is unknown. We have used specific interneuron markers including calcium binding proteins (parvalbumin, calbindin, and calretinin) and neuropeptides (somatostatin, neuropeptide Y, and cholecystokinin) together with either β1AR or β2AR to determine the distribution of these receptors in all major subfields of the hippocampus. We found that β1AR-expressing interneurons were more prevalent in the CA3 and CA1 regions of the hippocampus than in the dentate gyrus, where they were relatively sparse. β2AR-expressing interneurons were more uniformly distributed between all three regions of the hippocampus. A high proportion of neuropeptide Y-containing interneurons in the dentate gyrus co-expressed β2AR. β1AR labeling was common in interneurons expressing somatostatin and parvalbumin in the CA3 and CA1 regions, particularly in the stratum oriens of these regions. β2AR labeling was more likely to be found than β1AR labeling in cholecystokinin-expressing interneurons. In contrast, calretinin-containing interneurons were virtually devoid of β1AR or β2AR labeling. These regional and interneuron type-specific differences suggest functionally distinct roles for NA in modulating hippocampal activity via activation of βARs. © 2008 Wiley-Liss, Inc.


Publication metadata

Author(s): Cox DJ, Racca C, LeBeau FEN

Publication type: Article

Publication status: Published

Journal: Journal of Comparative Neurology

Year: 2008

Volume: 509

Issue: 6

Pages: 551-565

ISSN (print): 0021-9967

ISSN (electronic): 1096-9861

Publisher: John Wiley & Sons, Inc.

URL: http://dx.doi.org/10.1002/cne.21758

DOI: 10.1002/cne.21758

PubMed id: 18546278


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