Lookup NU author(s): Dr Simon Bomken,
Professor Julie Irving,
Professor Josef Vormoor
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We examined the leukemic stem cell potential of blasts at different stages of maturation in childhood acute lymphoblastic leukemia (ALL). Human leukemic bone marrow was transplanted intrafemorally into NOD/scid mice. Cells sorted using the B precursor differentiation markers CD19, CD20, and CD34 were isolated from patient samples and engrafted mice before serial transplantation into primary or subsequent (up to quaternary) recipients. Surprisingly, blasts representative of all of the different maturational stages were able to reconstitute and reestablish the complete leukemic phenotype in vivo. Sorted blast populations mirrored normal B precursor cells with transcription of a number of stage-appropriate genes. These observations inform a model for leukemia-propagating stem cells in childhood ALL. © 2008 Elsevier Inc. All rights reserved.
Author(s): le Viseur C, Hotfilder M, Bomken S, Wilson K, Röttgers S, Schrauder A, Rosemann A, Irving JAE, Stam R, Shultz L, Harbott J, Jürgens H, Schrappe M, Pieters R, Vormoor HJ
Publication type: Article
Publication status: Published
Journal: Cancer Cell
Print publication date: 08/07/2008
ISSN (print): 1535-6108
ISSN (electronic): 1878-3686
Publisher: Cell Press
PubMed id: 18598943
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