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Individual variation in 3-methylbutanal: A putative link between human leukocyte antigen and skin microflora

Lookup NU author(s): Dr Sergey Savelev, Sanjay Antony-Babu, Dr Craig Roberts, Dr Huitu Wang, Professor Tony Clare, Emeritus Professor Morris Gosling, Emerita Professor Marion Petrie, Emeritus Professor Michael Goodfellow, Professor Anthony O'Donnell, Emeritus Professor Alan Ward

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Abstract

The human derma emits volatile compounds whose interaction with a receiver's olfactory sensory system may affect individual recognition and mating preferences. Studies suggest that both genes and environmental factors determine characteristic odor of an individual. We used solid-phase microextraction and gas chromatography-mass spectrometry to identify 3-methylbutanal in human axillary odor; we showed that the abundance of this volatile compound varies significantly among individuals and demonstrated that its formation in vitro may be influenced by interaction between human leukocyte antigen peptide and dermal microflora. © 2008 Springer Science+Business Media, LLC.


Publication metadata

Author(s): Savelev SC, Antony-Babu S, Roberts S, Wang H, Clare AS, Gosling LM, Petrie M, Goodfellow M, O'Donnell A, Ward A

Publication type: Article

Publication status: Published

Journal: Journal of Chemical Ecology

Year: 2008

Volume: 34

Issue: 9

Pages: 1253-1257

Print publication date: 01/09/2008

ISSN (print): 0098-0331

ISSN (electronic): 1573-1561

Publisher: Springer

URL: http://dx.doi.org/10.1007/s10886-008-9524-1

DOI: 10.1007/s10886-008-9524-1


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