Lookup NU author(s): Professor Jim Edwardson,
Emeritus Professor Robert Perry,
Professor Ian McKeith,
Dr Christopher Morris
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The frequency of various allele types of the class I Major Histocompatibility Complex (MHC) genes HLA-A and HLA-B were compared between pathologically confirmed groups of late and early-onset Alzheimer's disease (AD) and a control group, DNA was extracted from frozen brain tissue and the highly polymorphic second and third exons of the HLA-A and HLA-B genes were independently PCR amplified using specific primers. Individual allele types were identified using sequence-specific oligonucleotide probes. The results showed that the main frequency differences occurred between the late-onset AD and the control group however none of these reached statistical significance. (C) 1999 Published by Elsevier Science Ireland Ltd. All rights reserved.
Author(s): McKeith I; Edwardson JA; Perry R; Morris C; Middleton D; Mawhinney H; Curran MD; Ince PG; Neill D
Publication type: Article
Publication status: Published
Journal: Neuroscience Letters
Print publication date: 01/03/1999
ISSN (print): 0304-3940
ISSN (electronic): 1872-7972
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