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Neuropathological substrates of dementia and depression in vascular dementia. with a particular focus on cases with small infarct volumes

Lookup NU author(s): Dr Clive Ballard, Professor Ian McKeith, Professor John O'Brien, Professor Raj Kalaria, Dr Evelyn Jaros, Emeritus Professor Robert Perry


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The neuropathological substrates of dementia and depression were evaluated in 30 patients with cerebrovascular disease and significant cognitive impairment (VaD), with a particular focus on patients with small infarct volumes (<15 ml). VaD patients with small infarct volumes had a similar degree of cognitive impairment to those with larger infarct volumes (>15 ml) but were significantly more likely to be depressed and to have areas of microinfarction. A review of individual cases with small infarct volumes suggested that the combination of microinfarction, diffuse white matter disease and perivascular changes, or the overlap of neurodegenerative pathologies and microvascular changes were particularly important. Microinfarction was also significantly associated with major depression. Copyright (C) 2000 S. Karger AG, Basel.

Publication metadata

Author(s): McKeith I; Kalaria R; Perry R; O'Brien J; Ballard C; Jaros E; Ince P

Publication type: Article

Publication status: Published

Journal: Dementia and Geriatric Cognitive Disorders

Year: 2000

Volume: 11

Issue: 2

Pages: 59-65

ISSN (print): 0077-8923

ISSN (electronic): 1749-6632

Publisher: Wiley-Blackwell Publishing Ltd.

URL: .htp://

DOI: 10.1159/000017215


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