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The CC chemokine receptor 5 Delta 32 mutation is not associated with inflammatory bowel disease (IBD) in NE England

Lookup NU author(s): Dr Alison Sutherland, Dr Mark Welfare, Dr Peter Donaldson, Dr John Mansfield

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Abstract

Inflammatory bowel disease (ISD) is a group of chronic inflammatory diseases of the gastrointestinal tract of unknown aetiology. Evidence of abnormalities in immune regulation and cytokine production in patients with IBD has led to investigations of various immune-regulatory genes as potential candidate susceptibility loci Studies using whole genome scanning have highlighted chromosomes 3, 7, 12 and 16. A 32 base-pair deletion in the CC-chemokine receptor-5 gene (CCR5-Delta 32, chromosome 3p21.3) has been associated with susceptibility to IBD. We have investigated CCR5 as a candidate susceptibility gene in 350 patients (251 with ulcerative colitis and 99 with Crohn's disease) and 103 controls using polymerase chain reaction. There were no significant differences in the distribution of CCR5 genotypes or frequencies comparing patients and controls, or associations with extent of colitis. In contrast to preliminary data, these findings suggest no evidence for involvement of this mutation in susceptibility/resistance or disease progression in IBD.


Publication metadata

Author(s): Craggs A, Welfare M, Donaldson PT, Mansfield JC

Publication type: Article

Publication status: Published

Journal: Genes and Immunity

Year: 2001

Volume: 2

Issue: 2

Pages: 114-116

ISSN (print): 1466-4879

ISSN (electronic): 1476-5470

Publisher: Nature Publishing Group

URL: http://dx.doi.org/10.1038/sj.gene.6363735

DOI: 10.1038/sj.gene.6363735


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