Lookup NU author(s): Justin Nissen,
Dr David Mantle,
Dr Barbara Gregson,
Professor Alexander Mendelow
Full text for this publication is not currently held within this repository. Alternative links are provided below where available.
Objectives-Adhesion molecules are involved in the pathogenesis of cerebral ischaemia and may play a part in the pathophysiology of delayed ischaemic neurological deficit (DIND) after aneurysmal subarachnoid haemorrhage. It was hypothesised that after aneurysmal subarachnoid haemorrhage, adhesion molecules may play a part in the pathophysiology of DIND as reflected by significantly altered serum concentrations in patients with and without DIND. Methods-In a prospective study, mean serum concentrations of ICAM-1, VCAM-1, PECAM, and E, P, and L-selectin were compared between patients without (n = 23) and with (n = 13) DIND in patients with World Federation of Neurological Surgeons (WFNS) grades 1 or 2 subarachnoid haemorrhage. Serum was sampled from patients within 2 days of haemorrhage and on alternate days until discharge. Concentrations of adhesion molecules were measured by standard procedures using commercially available enzyme linked immunoabsorbent assays. Results-There were non-significant differences in serum concentrations of ICAM-1 (290.8 ng/ml v 238.4 ng/ml, p = 0.0525), VCAM-1 (553.2 ng/ml v 425.8 ng/ml, p = 0.053), and PECAM (22.0 ng/ml v 21.0 ng/ml p = 0.56) between patients without and with DIND respectively. The E-selectin concentration between the two patient groups (44.0 ng/ml v 37.4 ng/ml, p = 0.33) was similar. The P-selectin concentration, however, was significantly higher in patients with DIND compared with those patients without DIND (149.5 ng/ml v 112.9 ng/ml, p = 0.039). By contrast, serum L-selectin concentrations were significantly lower in patients with DIND (633.8 ng/ml v 897.9 ng/ml, p = 0.013). Conclusions-Of all the adhesion molecules examined in this study, P and L-selectin are involved in the pathophysiology of DIND after aneurysmal subarachnoid haemorrhage.
Author(s): Mendelow AD; Gregson B; Mantle D; Nissen JJ
Publication type: Article
Publication status: Published
Journal: Journal of Neurology Neurosurgery and Psychiatry
ISSN (print): 0022-3050
Publisher: BMJ Publishing Group Ltd
Altmetrics provided by Altmetric