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Similar dose-response and persistence of erythema with broad-band and narrow-band ultraviolet B lamps

Lookup NU author(s): Dr Sharmila Das, Dr James Lloyd, Professor Peter Farr

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Abstract

Psoriasis may be treated with ultraviolet B from lamps that have a broad emission spectrum or, more effectively, with lamps that have a narrow emission spectrum at 311 +/- 2 nm. There are conflicting reports of either greater or lesser burning episodes with narrow-band compared to broad-band ultraviolet B, even when treatments are based on predetermined minimal erythema dose measurements. This suggests that either the characteristics of the dose-response curve for erythema or the time course for erythema may be different for the two lamps. We examined the erythemal response to narrowband and broad-band ultraviolet B in 12 patients with psoriasis. A geometric series of 10 doses from each lamp type were used on nonlesional skin on the back. Dose-response curves were constructed from reflectance measurements of erythema at 24 h and 72 h after irradiation. No significant difference was found in steepness of the erythema dose-response curve for the two lamps at 24 or 72 h. Persistence of erythema was assessed as the percentage of erythema remaining at 72 h. The mean persistence was 63% for narrow-band and 64% for broad-band lamps (p = 0.94). Therefore, in terms of erythemal response, no evidence has been found for a difference in burning potential for the two lamps.


Publication metadata

Author(s): Farr PM; Das S; Lloyd JJ

Publication type: Article

Publication status: Published

Journal: Journal of Investigative Dermatology

Year: 2001

Volume: 117

Issue: 5

Pages: 1318-1321

ISSN (print): 0022-202X

ISSN (electronic): 1523-1747

Publisher: Nature Publishing Group

URL: http://dx.doi.org/10.1046/j.0022-202x.2001.01511.x

DOI: 10.1046/j.0022-202x.2001.01511.x


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