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Designing inhibitors of cyclin-dependent kinases

Lookup NU author(s): Dr Ian Hardcastle, Professor Bernard Golding, Professor Roger Griffin

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Abstract

Cyclin-dependent kinases (cdks) play a pivotal role in controlling progression through the cell cycle. The complex mechanisms that control cdks have been elucidated and, in the case of cdk2, explained with reference to X-ray crystal structures of the catalytically active and inactive kinase. Deregulation of the cell cycle is commonly observed in cancer, so cdks are potential targets for experimental therapeutic agents. A number of distinct structural classes of cdk inhibitors have been discovered. Good selectivity among these ATP competitive inhibitors for cdks over other kinases has been established, and selectivity between individual cdks is often observed. The crystal structures of a number of key inhibitors bound to cdk2 can be used to explain the observed structure-activity relationships within the compound series and to guide the design of more potent inhibitors.


Publication metadata

Author(s): Hardcastle IR, Golding BT, Griffin RJ

Publication type: Review

Publication status: Published

Journal: Annual Review of Pharmacology and Toxicology

Year: 2002

Volume: 42

Pages: 325-348

ISSN (print): 0362-1642

ISSN (electronic): 1545-4304

URL: http://dx.doi.org/10.1146/annurev.pharmtox.42.090601.125940

DOI: 10.1146/annurev.pharmtox.42.090601.125940

PubMed id: 11807175


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