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CAMPATH-1M T-cell depleted BMT for SCID: Long-term follow-up of 19 children treated 1987-98 in a single center

Lookup NU author(s): Professor Andrew Gennery, Professor Anne Dickinson, Kenneth Brigham, Dr Gavin Spickett, Dr Ann Curtis, Vivien Spencer, Gary Cavanagh, Professor Andrew Cant, Dr Mario Abinun

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Abstract

Background SCID can be cured by BMT. Depletion of nature T cells from BM has enabled HLA non-identical stem-cell transplantation. We report the outcome of 30 patients treated with 37 T-cell depleted BMT procedures using CAMPATH-1M in vitro between 1987-98 in a single center. Methods Immune reconstitution and quality-of-life were assessed in 19 long-term survivors. All but two received pre-transplant conditioning. T- and B-cell chimerism, numbers and function were analyzed during a median follow-up of 5.3 years, (range 1.33-12). Results The overall engraftment rate was 59%, six children required repeated B-If T and the survival rate was 63%. All have donor T cells, 58% normal T-cell numbers and 74% normal T-cell function. Of 17 evaluated, 16 patients (94%) have normal IgM and IgG levels, and production of specific Abs to protein Ags, but only 5116 (31%) have a good response to pneumococcal polysaccharide. Early and late post-BMT complications were rare and there were no delayed deaths. Only one child continues on long-term i.v. Ig 4-years post-BAIT Eleven children died (37%). Discussion CAMPATH-1M T-cell depleted BMT for SCID resulted in 63% survival. Deaths of I I children were mainly due to pre-existing infections Seventeen of 19 long- term survivors have normal immune function and good quality-of-life.


Publication metadata

Author(s): Cavanagh G; Dickinson AM; Curtis A; Abinun M; Cant AJ; Spickett GP; Gennery AR; Brigham K; Barge D; Spencer V; Jackson A; Carter V; Palmer P; Flood TJ

Publication type: Article

Publication status: Published

Journal: Cytotherapy

Year: 2001

Volume: 3

Issue: 3

Pages: 221-232

Print publication date: 01/01/2001

ISSN (print): 1465-3249

ISSN (electronic): 1477-2566

Publisher: Informa Healthcare

URL: http://dx.doi.org/10.1080/146532401753174052

DOI: 10.1080/146532401753174052


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